The Hilton Jacksonville at Mayo Clinic opened with a two-day celebration, including a party on Sept. 30 and a ribbon cutting on Oct. 1.
The hotel is at 4745 Transformation Way on the south side of the Mayo Clinic in Florida campus. It can be accessed from an entrance off Butler Boulevard west of San Pablo Road South.
The event marked the conclusion of a project that began in 2019 and faced the challenges of the coronavirus pandemic, fluctuating construction costs and high interest rates.
When the project was announced in September 2021, the projected cost was $70 million.
Construction of the eight-story, 252-room hotel began in 2023. It was built by North Carolina-based Concord Hospitality Enterprises and the California-based Whitman Peterson private equity real estate company, in collaboration with Mayo Clinic.
The building totals 184,000 square feet. It was designed by the DLR Group of Orlando.
It is Jacksonville’s first full-service hotel built in the
past two decades and is managed by Concord Hospitality.
“This new hotel strengthens our commitment to providing a healing environment that extends beyond clinical care. For our patients and their families, it offers a warm, supportive place to stay just steps away from the care they need,” Dr. Kent Thielen, CEO of Mayo Clinic in Florida, said in an email.
“And for Jacksonville, it contributes to economic growth and deepens our connection to the community. Together, we are creating an environment where care, comfort, and community come together in a meaningful way.”
Jacksonville Mayor Donna Deegan spoke at the Sept. 30 event.
She announced the property will serve as the official host hotel for the 2026 Donna Marathon.
Hilton and its partners presented The Donna Foundation with a $12,500 check for its Northeast Florida Financial Aid Fund, used to help those in need pay for breast cancer care.
Deegan, a three-time breast cancer survivor, started the foundation in 2003.
“Obviously, this does not happen without the Mayo Clinic. We have needed something like this out here in this area of town for so long. We need it for Jacksonville,” Deegan said.
“With the Four Seasons coming Downtown and several other hotels on the drawing board, this is just the beginning of what you’re going to see for years to come with a city on the rise.”
While on the Mayo campus, the hotel will serve patients and their families as well as tourists and business customers.
Amenities include:
• 252 guest rooms, featuring 21 suites, with water and nature views.
• More than 21,000 square feet of event space to host gatherings, including a 10,000-square-foot pillarless ballroom, a 3,000-square-foot junior ballroom and boardrooms.
• A 5,000-square-foot event lawn.
• Heated, zero-entry pool and a covered outdoor terrace.
• A 24-hour fitness center.
• Lobby coffee shop serving smoothies and grab-and-go breakfast and lunch items.
• In-room dining service.
“Whether guests are here to support a loved one, celebrate a milestone, or simply enjoy the beauty of Northeast Florida, our goal is to provide genuine care, comfort, and memorable experiences that reflect both Hilton’s legacy and the spirit of this community,” hotel general manager Jayson Zimmer said in a news release.
Coastal Kitchen is the hotel’s restaurant under the direction of executive chef Andrew Kallsnick.
The menu will feature local seafood.
The opening of a full-service Hilton property is an important step in generating tourist dollars, Michael Corrigan, president and CEO of Visit Jacksonville said.
“Hilton and Mayo Clinic are synonymous with quality. I can’t tell you how important this is to us,” he said.
“This is located off J. Turner Butler Boulevard. It’s the gateway to the Beaches. It’s minutes away from Town Center and about 15 minutes away from destinations that are equally important. A new full-service hotel is exactly what Jacksonville needs."
