U.S. Rep. Ander Crenshaw easily defeated two Republican opponents and won re-election to represent Congress District 4. Crenshaw accumulated almost 46,000 of the close to 64,000 votes cast, good for close to 72 percent. Bob Black finished second with 18 percent of the vote, followed by Deborah Katz Pueschel with 10 percent. No Democrat was in the running for the seat, meaning Crenshaw will retain the seat he has held since 2001. The district consists of all of Baker, Columbia, Hamilton, Madison, Nassau and Union counties and includes parts of Duval, Jefferson and Leon counties.
| Ander Crenshaw | 45,958 | (71.9%) |
| Bob Black | 11,585 | (18.1%) |
| Deborah Katz Pueschel | 6,391 | (10%) |